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Publications

At Syracuse University

5. Xuancheng Fu, Bowen Xu, Suman Maity, Michelle Wu, Luke G. Westbrook, Katie Edwards, Atanu Acharya,* Xiaoran Hu* "Bioorthogonal Regulation of Self-Immolation and Controlled Release Using Cucurbit[7]uril Supramolecular Chemistry" Submitted.

Preprint available on ChemRxiv:  DOI: 10.26434/chemrxiv-2024-m7rrb

4. Cijun Zhang, Tatiana B. Kouznetsova, Boyu Zhu, Liam Sweeney, Max Lancer, Ivan Gitsov, Stephen L. Craig,  Xiaoran Hu* "Advancing the Mechanosensitivity of Atropisomeric Diarylethene Mechanophores Through a Lever-Arm Effect" Submitted. 

Preprint available on ChemRxiv: DOI: 10.26434/chemrxiv-2024-smxcc

3. Xuancheng Fu, Xiaoran Hu* "Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic TherapyACS Applied Bio Materials 2024 in press.

DOI: 10.1021/acsabm.4c00150

Featured in:

Journal Cover, ACS Applied Biomaterials

2024 Early Career Forum, ACS Applied Materials family of journals

Before Syracuse University (2022 and before)

•   Husic, C. C.; Hu, X; Robb, M. J. “Incorporation of a Tethered Alcohol Enables Efficient Mechanically Triggered Release in Aprotic Environments”, ACS Macro Lett. 2022, 11, 948-953.

•   Versaw, B; Zeng, T; Hu, X; Robb, M. J. “Harnessing the Power of Force: Development of Mechanophores for Molecular Release” J. Am. Chem. Soc. 2021, 143, 21461-21473.

•   Zeng, T; Hu, X; Robb, M. J. “5-Aryloxy Substitution Enables Efficient Mechanically Triggered Release from a Synthetically Accessible Masked 2-Furylcarbinol Mechanophore” Chem. Commun., 2021, 57, 11173-11176.

•   Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Release of Functionally Diverse Molecular Payloads from Masked 2-Furylcarbinol Derivatives” ACS Cent. Sci. 2021, 7, 1216-1224. 

doi.org/10.1021/acscentsci.1c00460

furan maleimide diels-alder adduct mechanophore mechanically triggered release

•   Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Small Molecule Release from a Masked Furfuryl Carbonate” J. Am. Chem. Soc. 2019, 141, 15018-15023. doi.org/10.1021/jacs.9b08663

Featured in Caltech News

Featured in JACS Spotlights

furan maleimide diels-alder adduct mechanophore mechanically triggered release

• Barber, R. W.; McFadden, M. E.; Hu, X.; and Robb, M. J. “Mechanochemically Gated Photoswitching: Expanding the Scope of Polymer Mechanochromism” Synlett 2019, 30, 1725–1732.

Hu, X.; McFadden, M. E.; Baber, R. W.; Robb, M. J. “Mechanochemical Regulation of a Photochemical Reaction” J. Am. Chem. Soc. 2018, 140, 14073-14077.  

doi.org/10.1021/jacs.8b09628

Featured in Nature Reviews Chemistry

Diarylethene mechanophore mechanically gated photoswitch

• Feeney M. J.; Hu, X.; Srinivasan R.; Van N.; Hunter M.; Georgakoudi I.; Thomas S. W. III “UV and NIR-Responsive Layer-by-Layer Films Containing 6-Bromo-7-hydroxycoumarin Photolabile Groups” Langmuir 2017, 33, 10877–10885.

Hu, X.; Lawrence, J. A.; Mullahoo, J.; Smith, Z. C; Wilson, D. J.; Mace, C. R.; Thomas, S. W. III “Directly Photopatternable Polythiophene as Dual-Tone Photoresist” Macromolecules 2017, 50, 7258–7267. doi.org/10.1021/acs.macromol.7b01208

Photolithography photoresist p3ht nitrobenzyl polymer patterning

• Kaner, P.; Hu, X.; Thomas, S. W. III, Asatekin, A. “Self-Cleaning Membranes from Comb-Shaped Copolymers with Photoresponsive Side Groups” ACS Appl. Mater. Interfaces 2017, 9, 13619–13631.

Hu, X.; Qureishi, Z.; Thomas, S. W. III "Light-Controlled Selective Disruption, Multi-Level Patterning, and Sequential Release with Polyelectrolyte Multilayer Films Incorporating Four Photocleavable Chromophores” Chem. Mater. 2017, 29, 2951-2960.   doi.org/10.1021/acs.chemmater.6b05294

photopatternable layer-by-layer polyelectrolyte film nanofilm

Hu, X.; Feeney, M. J.; McIntosh, E.; Mullahoo, J.; Jia, F.; Xu, Q.; Thomas, S. W. III "Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes" ACS Appl. Mater. Interfaces 2016, 8, 23517–23522.  

doi.org/10.1021/acsami.6b07366

photoresponsive polyelectrolyte nanoparticles

Hu, X.; Macintosh, E; Simon, M. G.; Staii, C.; Thomas, S. W. III "Stimuli-Responsive Free-Standing Layer-By-Layer Films" Adv. Mater. 2016, 28, 715–721.

doi.org/10.1002/adma.201504219

photoresponsive nanofilm freestanding

• Hu, X.; Shi, J.; Thomas, S. W. III "Photolabile ROMP Gels Using ortho-Nitrobenzyl Functional Crosslinkers” Polym. Chem. 2015, 6, 4966–4971.  

doi.org/10.1039/C5PY00562K

photoresponsive romp gel nitrobenzyl

• Gumbley, P.; Hu, X.; Lawrence, J. A., III; Thomas, S. W. III "Photoresponsive Gels Prepared by Ring Opening Metathesis Polymerization” Macromol. Rapid Commun. 2013, 34, 1838–1843.

Patents

(8) Hu, X. Provisional US patent application submitted (Syracuse University, to be updated)

(7) Hu, X.; Fu, X. "Controlled Release of Covalently Conjugated Molecules Using Host-Guest Interactions" Provisional US Patent App. 63/702,109 Oct 1, 2024. (Syracuse University)

(6) Hu, X.; Fu, X. "Mechanophore with Force Triggered Stereochemistry Conversion" US Patent App. 18/656,114, May 6, 2024. (Syracuse University)

(5) Robb, M. J.; Hu, X. “Mechanical Regulation of Photoswitching” US11834442B2, Granted December 5, 2023. (California Institute of Technology)

(4) Robb, M. J.; Hu, X.; Zeng, T. “Method for Controlled Release Using Mechanical Force” US11584752B2t, Granted February 21, 2023. (California Institute of Technology)

(3) Hu, X.; Zhu, S.; Robisson, A.; Qu, M; Ossia, S. “Methods for Ring-Opening Metathesis Polymerization (ROMP) for In-Situ Formation of High Glass Transition Temperature (Tg) Polymers” US11,377,580, Granted July 5, 2022. (Schlumberger Technology Corporation)

(2) Luozhong, S.; Yuan, Z.; Jiang, S.; Hu, X.; Bailey, S. "Zwitterionic Lipid Nanoparticle Compositions, and Methods of Use" US Patent App. 63/129,343, published June 30, 2022. (Cornell) 

(1) Asatekin, A.; Thomas, S. W. III; Kaner, P.; Hu, X. “Two-layer photo-responsive membranes” US10,603,637, Granted March 31, 2020. (Tufts University)

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