Publications
At Syracuse University
5. Xuancheng Fu, Bowen Xu, Suman Maity, Michelle Wu, Luke G. Westbrook, Katie Edwards, Atanu Acharya,* Xiaoran Hu* "Bioorthogonal Regulation of Self-Immolation and Controlled Release Using Cucurbit[7]uril Supramolecular Chemistry" Submitted.
Preprint available on ChemRxiv: DOI: 10.26434/chemrxiv-2024-m7rrb
4. Cijun Zhang, Tatiana B. Kouznetsova, Boyu Zhu, Liam Sweeney, Max Lancer, Ivan Gitsov, Stephen L. Craig, Xiaoran Hu* "Advancing the Mechanosensitivity of Atropisomeric Diarylethene Mechanophores Through a Lever-Arm Effect" Submitted.
Preprint available on ChemRxiv: DOI: 10.26434/chemrxiv-2024-smxcc
3. Xuancheng Fu, Xiaoran Hu* "Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy" ACS Applied Bio Materials 2024 in press.
Featured in:
Journal Cover, ACS Applied Biomaterials
2024 Early Career Forum, ACS Applied Materials family of journals
1. Xuancheng Fu, Boyu Zhu, Xiaoran Hu* “Force-Triggered Atropisomerization of a Parallel Diarylethene to Its Anti-Parallel Diastereomers” Journal of the American Chemical Society 2023, 145, 15668-15673.
Featured in: Synfacts
Before Syracuse University (2022 and before)
• Husic, C. C.; Hu, X; Robb, M. J. “Incorporation of a Tethered Alcohol Enables Efficient Mechanically Triggered Release in Aprotic Environments”, ACS Macro Lett. 2022, 11, 948-953.
• Versaw, B; Zeng, T; Hu, X; Robb, M. J. “Harnessing the Power of Force: Development of Mechanophores for Molecular Release” J. Am. Chem. Soc. 2021, 143, 21461-21473.
• Zeng, T; Hu, X; Robb, M. J. “5-Aryloxy Substitution Enables Efficient Mechanically Triggered Release from a Synthetically Accessible Masked 2-Furylcarbinol Mechanophore” Chem. Commun., 2021, 57, 11173-11176.
• Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Release of Functionally Diverse Molecular Payloads from Masked 2-Furylcarbinol Derivatives” ACS Cent. Sci. 2021, 7, 1216-1224.
• Hu, X; Zeng, T; Husic, C. C.; Robb, M. J. “Mechanically Triggered Small Molecule Release from a Masked Furfuryl Carbonate” J. Am. Chem. Soc. 2019, 141, 15018-15023. doi.org/10.1021/jacs.9b08663
Featured in Caltech News
• Barber, R. W.; McFadden, M. E.; Hu, X.; and Robb, M. J. “Mechanochemically Gated Photoswitching: Expanding the Scope of Polymer Mechanochromism” Synlett 2019, 30, 1725–1732.
• Hu, X.; McFadden, M. E.; Baber, R. W.; Robb, M. J. “Mechanochemical Regulation of a Photochemical Reaction” J. Am. Chem. Soc. 2018, 140, 14073-14077.
Featured in Nature Reviews Chemistry
• Feeney M. J.; Hu, X.; Srinivasan R.; Van N.; Hunter M.; Georgakoudi I.; Thomas S. W. III “UV and NIR-Responsive Layer-by-Layer Films Containing 6-Bromo-7-hydroxycoumarin Photolabile Groups” Langmuir 2017, 33, 10877–10885.
• Hu, X.; Lawrence, J. A.; Mullahoo, J.; Smith, Z. C; Wilson, D. J.; Mace, C. R.; Thomas, S. W. III “Directly Photopatternable Polythiophene as Dual-Tone Photoresist” Macromolecules 2017, 50, 7258–7267. doi.org/10.1021/acs.macromol.7b01208
• Kaner, P.; Hu, X.; Thomas, S. W. III, Asatekin, A. “Self-Cleaning Membranes from Comb-Shaped Copolymers with Photoresponsive Side Groups” ACS Appl. Mater. Interfaces 2017, 9, 13619–13631.
• Hu, X.; Qureishi, Z.; Thomas, S. W. III "Light-Controlled Selective Disruption, Multi-Level Patterning, and Sequential Release with Polyelectrolyte Multilayer Films Incorporating Four Photocleavable Chromophores” Chem. Mater. 2017, 29, 2951-2960. doi.org/10.1021/acs.chemmater.6b05294
• Hu, X.; Feeney, M. J.; McIntosh, E.; Mullahoo, J.; Jia, F.; Xu, Q.; Thomas, S. W. III "Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes" ACS Appl. Mater. Interfaces 2016, 8, 23517–23522.
doi.org/10.1021/acsami.6b07366
• Hu, X.; Macintosh, E; Simon, M. G.; Staii, C.; Thomas, S. W. III "Stimuli-Responsive Free-Standing Layer-By-Layer Films" Adv. Mater. 2016, 28, 715–721.
• Hu, X.; Shi, J.; Thomas, S. W. III "Photolabile ROMP Gels Using ortho-Nitrobenzyl Functional Crosslinkers” Polym. Chem. 2015, 6, 4966–4971.
• Gumbley, P.; Hu, X.; Lawrence, J. A., III; Thomas, S. W. III "Photoresponsive Gels Prepared by Ring Opening Metathesis Polymerization” Macromol. Rapid Commun. 2013, 34, 1838–1843.
Patents
(8) Hu, X. Provisional US patent application submitted (Syracuse University, to be updated)
(7) Hu, X.; Fu, X. "Controlled Release of Covalently Conjugated Molecules Using Host-Guest Interactions" Provisional US Patent App. 63/702,109 Oct 1, 2024. (Syracuse University)
(6) Hu, X.; Fu, X. "Mechanophore with Force Triggered Stereochemistry Conversion" US Patent App. 18/656,114, May 6, 2024. (Syracuse University)
(5) Robb, M. J.; Hu, X. “Mechanical Regulation of Photoswitching” US11834442B2, Granted December 5, 2023. (California Institute of Technology)
(4) Robb, M. J.; Hu, X.; Zeng, T. “Method for Controlled Release Using Mechanical Force” US11584752B2t, Granted February 21, 2023. (California Institute of Technology)
(3) Hu, X.; Zhu, S.; Robisson, A.; Qu, M; Ossia, S. “Methods for Ring-Opening Metathesis Polymerization (ROMP) for In-Situ Formation of High Glass Transition Temperature (Tg) Polymers” US11,377,580, Granted July 5, 2022. (Schlumberger Technology Corporation)
(2) Luozhong, S.; Yuan, Z.; Jiang, S.; Hu, X.; Bailey, S. "Zwitterionic Lipid Nanoparticle Compositions, and Methods of Use" US Patent App. 63/129,343, published June 30, 2022. (Cornell)
(1) Asatekin, A.; Thomas, S. W. III; Kaner, P.; Hu, X. “Two-layer photo-responsive membranes” US10,603,637, Granted March 31, 2020. (Tufts University)